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apalutamide will minimize the level or effect of modafinil by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Keep away from or Use Alternate Drug. Coadministration of apalutamide, a robust CYP3A4 inducer, with medicine which might be CYP3A4 substrates may end up in lower publicity to these drugs.posaconazole will boost the degree or result